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It is possible to create variants of a product with different SKU numbers in Shopify, making it highly flexible for managing inventory and sales. Each variant can have its own unique SKU, which is beneficial for identifying and tracking specific variations of a product, such as size, color, or material. This capability allows merchants to keep precise records and manage stock levels effectively, catering to various customer preferences without confusion.

The ability to assign different SKUs to each variant is particularly useful for businesses that require detailed inventory management, as it helps streamline processes such as order fulfillment and stock tracking. By utilizing this feature, merchants can ensure that they are able to differentiate between similar items and reduce the risk of errors when managing their product catalog.

This functionality applies uniformly across all product types, not just limited to particular categories or numbers of variants, enhancing the overall usability and adaptability of the Shopify platform in catering to diverse product lines.